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  • Title: Cholesterol depletion reduces aggregation of amyloid-beta peptide in hippocampal neurons.
    Author: Schneider A, Schulz-Schaeffer W, Hartmann T, Schulz JB, Simons M.
    Journal: Neurobiol Dis; 2006 Sep; 23(3):573-7. PubMed ID: 16777421.
    Abstract:
    A key event in the pathogenesis of Alzheimer's disease is the conversion of soluble amyloid Abeta-peptide into toxic aggregates. Here, we studied the effect of cholesterol depletion on the formation of insoluble Abeta. We found that reduction of neuronal cholesterol by approximately 25% reduced the neuronal formation of insoluble Abeta without affecting the secretion of soluble Abeta. Moreover, we demonstrate that Abeta-oligomers from Alzheimer's disease brains associate with a detergent-resistant membrane fraction in a cholesterol-dependent manner. These results suggest a key role for cholesterol in aggregation of Abeta.
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