These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Heat shock protein-90 inhibitors: a chronicle from geldanamycin to today's agents.
    Author: Chiosis G, Caldas Lopes E, Solit D.
    Journal: Curr Opin Investig Drugs; 2006 Jun; 7(6):534-41. PubMed ID: 16784024.
    Abstract:
    Heat shock protein (Hsp)90 is a chaperone with essential roles in maintaining transformation and in elevating the survival and growth potential of cancer cells. The recognition of Hsp90 as an important target in cancer therapy has prompted the identification, development and clinical translation of a large array of Hsp90 inhibitors. This review discusses the modalities that may interfere with this chaperone's function and describes the status of existing and emerging Hsp90 inhibitor classes.
    [Abstract] [Full Text] [Related] [New Search]