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  • Title: Synthesis and antibacterial activity of C12 des-methyl ketolides.
    Author: Lin X, Rico AC, Chu DT, Carroll GL, Barker L, Shawar R, Desai MC, Plattner JJ.
    Journal: Bioorg Med Chem Lett; 2006 Sep 01; 16(17):4692-6. PubMed ID: 16784845.
    Abstract:
    Synthesis of C(12) des-methyl ketolide is developed featuring an intramolecular epoxide formation/elimination process to establish the C(12) stereocenter. These ketolides are potent against several key respiratory pathogens, including erythromycin resistant erm- and mef-containing strains of Streptococcus pneumoniae.
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