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  • Title: AID and Igh switch region-Myc chromosomal translocations.
    Author: Unniraman S, Schatz DG.
    Journal: DNA Repair (Amst); 2006 Sep 08; 5(9-10):1259-64. PubMed ID: 16784901.
    Abstract:
    Chromosomal translocations involving Ig heavy chain switch regions and an oncogene, like Myc, represent early initiating events in the development of many B cell malignancies. These translocations are widely believed to result from aberrant class switch recombination (CSR). Recent reports have produced conflicting models for the role of activation-induced cytidine deaminase (AID) in this process. Here, we discuss possible roles of AID, CSR, and somatic hypermutation in generating chromosomal translocations and in tumor progression.
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