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  • Title: Solution-phase molecular-scale computation with deoxyribozyme-based logic gates and fluorescent readouts.
    Author: Macdonald J, Stefanovic D, Stojanovic MN.
    Journal: Methods Mol Biol; 2006; 335():343-63. PubMed ID: 16785637.
    Abstract:
    Recent development of solution-phase molecular-scale Boolean calculations using deoxyribozymes is potentially an important step toward the development of autonomous therapeutic and diagnostic devices. Here, the construction of basic YES, AND, ANDNOT, and ANDANDNOT deoxyribozyme-based logic gates is described. Protocols for testing gate activity using fluorescent oligonucleotide probes have been provided, and pointers for gate optimization are included.
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