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  • Title: Calcineurin inhibitor-induced irreversible neuropathic pain after allogeneic hematopoietic stem cell transplantation.
    Author: Fujii N, Ikeda K, Koyama M, Aoyama K, Masunari T, Kondo E, Matsuzaki T, Mizobuchi S, Hiraki A, Teshima T, Shinagawa K, Ishimaru F, Tanimoto M.
    Journal: Int J Hematol; 2006 Jun; 83(5):459-61. PubMed ID: 16787880.
    Abstract:
    The calcineurin inhibitors (CIs) cyclosporine A and tacrolimus are essential for graft-versus-host disease prophylaxis but are associated with adverse effects, including neurotoxicity. We report a case of irreversible CI-induced neuropathic pain following allogeneic hematopoietic stem cell transplantation. The patient developed dysesthesia, electric shock-like pain, and severe itching followed by intractable analgesic-resistant pain in the lower extremities. There were no abnormal radiographic findings, and there was no improvement with a reduction of CI dosage or with administration of a calcium channel blocker. These clinical findings are similar to but inconsistent with CI-induced musculoskeletal pain syndromes previously reported in organ transplantation.
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