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  • Title: Clinical, histopathological and immunohistochemical findings in a case of megakaryoblastic leukemia in a dog.
    Author: Park HM, Doster AR, Tashbaeva RE, Lee YM, Lyoo YS, Lee SJ, Kim HJ, Sur JH.
    Journal: J Vet Diagn Invest; 2006 May; 18(3):287-91. PubMed ID: 16789720.
    Abstract:
    The clinical, hematological, and histopathologic features of megakaryoblastic leukemia (M7) were investigated in a 10-year-old female Shih-Tzu dog. Megakaryoblastic leukemia was diagnosed using anti-human platelet glycoprotein (GP IIIa) and anti-human von Willebrand factor (vWF) antibodies. The expression of CD antigen on megakaryoblasts was also assessed using a CD79a monoclonal antibody. Immunological markers allowed visualization of neoplastic megakaryocytes. Antibodies against platelet GP IIIa were demonstrated to be the most useful for the diagnosis of megakaryoblastic leukemia of paraffin-embedded canine tissues. Hematological and histological data coupled with immunohistochemical reactivity for platelet GP IIIa, vWF, and CD79a antigen in blast cells confirmed a diagnosis of M7 megakaryoblastic leukemia.
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