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  • Title: Transient neonatal Cryptosporidium parvum infection triggers long-term jejunal hypersensitivity to distension in immunocompetent rats.
    Author: Marion R, Baishanbo A, Gargala G, François A, Ducrotté P, Duclos C, Fioramonti J, Ballet JJ, Favennec L.
    Journal: Infect Immun; 2006 Jul; 74(7):4387-9. PubMed ID: 16790818.
    Abstract:
    In 5-day-old immunocompetent Sprague-Dawley rats infected with either 10(2) or 10(5) Cryptosporidium parvum oocysts, transient infection resulted 120 days later in increased cardiovascular depressor response to jejunal distension and jejunal myeloperoxidase activity (P < 0.05). Nitazoxanide treatment normalized jejunal sensitivity (P < 0.001) but not myeloperoxidase levels (P > 0.05). Data warrant further evaluation of the role of early cryptosporidiosis in the development of chronic inflammatory gut conditions.
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