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  • Title: Catalytic asymmetric synthesis of alpha- and beta-amino phosphonic acid derivatives.
    Author: Ma JA.
    Journal: Chem Soc Rev; 2006 Jul; 35(7):630-6. PubMed ID: 16791334.
    Abstract:
    Catalytic asymmetric reactions provide one of the most powerful and economical synthetic approaches to a variety of enantiomerically enriched compounds. As being analogues of the corresponding alpha- and beta-amino acids, optically active alpha- and beta-amino phosphonic acid derivatives have found widespread use in medicinal chemistry and the pharmaceutical sciences. Using catalytic amounts of chiral materials, asymmetric synthesis of enantiomerically enriched alpha- and beta-amino phosphonates has been a subject of growing interest. This tutorial review contains a compilation of the catalytic asymmetric synthetic methods developed to date and highlights their utility for obtaining these target compounds.
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