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  • Title: Synthesis and biological assays of E-ring analogs of camptothecin and homocamptothecin.
    Author: Tangirala RS, Antony S, Agama K, Pommier Y, Anderson BD, Bevins R, Curran DP.
    Journal: Bioorg Med Chem; 2006 Sep 15; 14(18):6202-12. PubMed ID: 16793274.
    Abstract:
    Analogs of the anti-tumor agent camptothecin with both closed E-rings (lactone and ether) and open E-rings (reduced acid, hydrazide, and protected Weinreb amide) have been prepared and tested in topoisomerase and cellular assays. The results provide insights into the structural features of the camptothecin E-ring that affect biological activity.
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