These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Development of an anti-infection nano-hydroxypatite drug delivery microsphere and its drug-release in vitro].
    Author: Wang YF, Jin AM, Wei K, Wang XD, Tang SH, Min SX.
    Journal: Nan Fang Yi Ke Da Xue Xue Bao; 2006 Jun; 26(6):754-6. PubMed ID: 16793592.
    Abstract:
    OBJECTIVE: To develop an anti-infection nano-hydroxypatite (nano-HA) microsphere for local drug delivery for treating osteomyelitis. METHODS: The nano-HA was used as the core carrier to load gentamicin (GM) and coated with poly(-hydroxybutyrate-co- hydroxyvalerate)/polyethylene glycol (PHBV/PEG), which was degradable and biocompatible, to prepare nano-HA-PHBV/PEG-GM microsphere. The surface structure and in vitro drug-release of the microsphere were studied. RESULTS: The microsphere had good drug delivery capability. The samples weighing 90 mg each were soaked in PBS and gentamicin release within the first day was 165.2 microg/ml, which maintained a low release rate in the following days. After 28 days, gentamicin release declined to 8.5 microg/ml, which was higher than the minimal inhibitory concentration of gentamicin (2 microg/ml). CONCLUSION: The local drug delivery system has good drug-release performance in vitro and may possess potential value in clinical management of osteomyelitis.
    [Abstract] [Full Text] [Related] [New Search]