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  • Title: Treatment of diffuse cutaneous leishmaniasis with miltefosine: a case report.
    Author: Zerpa O, Blanco B, Kannee C, Ulrich M, Sindermann H, Engel J, Convit J.
    Journal: Int J Dermatol; 2006 Jun; 45(6):751-3. PubMed ID: 16796642.
    Abstract:
    BACKGROUND: A 31-year-old man who has suffered since age 3 from diffuse cutaneous leishmaniasis (DCL), a disease with profound physical and psychosocial repercussions and no effective treatment at present, was treated with miltefosine. METHODS: The patient was treated for 120 days, 100 mg/day for 1 week, then 150 mg/day subsequently. RESULTS: Lesions were free of parasites at 43 days, and no signs of infiltration were present at day 76. No adverse side effects were observed. CONCLUSIONS: The dramatic clinical effect of miltefosine in this patient appears to fully justify further evaluation of this experimental therapy in DCL.
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