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  • Title: Effects of single and multiple doses of itraconazole on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein.
    Author: Shimizu M, Uno T, Sugawara K, Tateishi T.
    Journal: Br J Clin Pharmacol; 2006 Sep; 62(3):372-6. PubMed ID: 16796706.
    Abstract:
    AIMS: We determined whether or not the extent of drug interaction of fexofenadine by itraconazole is time-dependent. METHODS: In a randomized two-phase crossover study, itraconazole was administered orally for 6 days, and, on days 1, 3 and 6, fexofenadine was administered simultaneously. On another occasion, fexofenadine was administered alone. RESULTS: Itraconazole increased fexofenadine AUC(0, infinity), and the % change for difference was 178% (95% CI 1235, 3379), 205% (95% CI 1539, 3319) and 169% (95% CI 1128, 2987) on days 1, 3 and 6 of the 6 day treatment, respectively. CONCLUSIONS: The extent of drug interaction by itraconazole was not time-dependent.
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