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  • Title: Sirolimus-induced intractable chronic diarrhea: a case report.
    Author: Alkhatib AA.
    Journal: Transplant Proc; 2006 Jun; 38(5):1298-300. PubMed ID: 16797287.
    Abstract:
    Sirolimus is a macrolide that is extensively used in transplant clinics. The most common side effects of sirolimus are hypertriglyceridemia, hypercholesterolemia, hypertension, rash, and well-tolerated diarrhea. Herein I have reported a case of intractable, disabling, chronic diarrhea secondary to sirolimus in a renal transplant recipient. The sirolimus dose had been recently increased from 2 mg to 5 mg 1 month before the patient began to complain of severe diarrhea. In addition to the case presentation, the literature is reviewed as well as possible mechanisms of sirolimus-induced diarrhea are discussed. In conclusion, clinicians should consider sirolimus as a potential etiology for severe chronic diarrhea among patients who are treated with sirolimus.
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