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  • Title: Hemophagocytic syndrome after adult-to-adult living donor liver transplantation.
    Author: Akamatsu N, Sugawara Y, Tamura S, Matsui Y, Hasegawa K, Imamura H, Kokudo N, Makuuchi M.
    Journal: Transplant Proc; 2006 Jun; 38(5):1425-8. PubMed ID: 16797322.
    Abstract:
    Hemophagocytic syndrome is a fatal complication after liver transplantation that is rarely reported. Among 260 adult patients who underwent living donor liver transplantation at our hospital, three cases (1%) were complicated with hemophagocytic syndrome. Intensive investigation revealed Aspergillus, cytomegalovirus, and hepatitis C virus as the most likely causative organisms in each patient. Despite the immediate initiation of anti-infectious treatment and supportive care, all patients died. When pancytopenia with possible underlying infectious disease is observed in liver transplant recipients, hemophagocytic syndrome should be suspected and bone marrow biopsy considered. The prognosis of hemophagocytic syndrome remains poor and further investigations are required to establish effective therapeutic options.
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