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  • Title: Intracranial hemorrhage due to late hemorrhagic disease in two siblings.
    Author: Per H, Kumandaş S, Ozdemir MA, Gümüş H, Karakukcu M.
    Journal: J Emerg Med; 2006 Jul; 31(1):49-52. PubMed ID: 16798155.
    Abstract:
    Deficiency of vitamin K predisposes to early, classic or late hemorrhagic disease of the newborn (HDN); late HDN may be associated with serious and life-threatening intracranial hemorrhage. Late HDN is characterized by intracranial bleeding in infants aged 1 week to 6 months due to severe vitamin K deficiency, occurring particularly in exclusively breastfed infants. Late HDN is still an important cause of mortality and morbidity in developing countries where vitamin K prophylaxis is not routinely practiced. In this study, we report on two siblings with intracranial bleeding who were fully breastfed without a routine supplementation of vitamin K. Vitamin K should be given to all newborns as a single, intramuscular dose of 1 mg.
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