These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Heat-shock protein 70 genes and human longevity: a view from Denmark.
    Author: Singh R, Kølvraa S, Bross P, Christensen K, Gregersen N, Tan Q, Jensen UB, Eiberg H, Rattan SI.
    Journal: Ann N Y Acad Sci; 2006 May; 1067():301-8. PubMed ID: 16804002.
    Abstract:
    We have studied the association of three single nucleotide polymorphisms (SNPs) present in the three HSP70 (heat-shock protein) genes on 6p21 with human longevity. The availability of biological samples from various population cohorts in Denmark has given us the opportunity to try novel methods of gene association with human longevity. A significant association of one haplotype with male longevity was observed. Furthermore, a significant difference in the survival of the carriers of the different genotypes in females was observed. We also found an age-dependant decline in the ability of peripheral blood mononuclear cells to respond to heat stress in terms of Hsp70 induction.
    [Abstract] [Full Text] [Related] [New Search]