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  • Title: mRNA expression of MAGE-A3 gene in leukemia cells.
    Author: Martínez A, Olarte I, Mergold MA, Gutiérrez M, Rozen E, Collazo J, Amancio-Chassin O, Ordóñez RM, Montesinos JJ, Mayani H, McCurdy DK, Ostrosky-Wegman P, Garrido-Guerrero E, Miranda EI.
    Journal: Leuk Res; 2007 Jan; 31(1):33-7. PubMed ID: 16806467.
    Abstract:
    Leukemia-associated antigens such as proteins encoded by MAGE genes might provide tools for immunotherapy of leukemia. Positive and negative results of MAGE-A gene expression in hematological malignancies have been reported. This led us to study MAGE-A gene expression in human leukemias using RT-PCR. Among 115 leukemias from various subtypes, 14/34 (41.17%) AML were positive for one of the three genes analyzed (MAGE-A1 1/32; MAGE-A3 10/32; MAGE-B2 3/12). Expression was also detected in 23/76 (30.26%) B-cell ALL patients (MAGE-A1 2/53; MAGE-A3 20/53; MAGE-B2 1/32). One of these patients expressed both MAGE-A1 (weak signal) and -A3 (strong signal) genes. Other patient with CML were positive for MAGE-B2 (1/5, 20%). MAGE-A3 expression data were corroborated by real time RT-PCR through determination of MAGE-A3 transcript levels. We concluded that the MAGE-A3 gene is expressed at the mRNA level in a proportion of human leukemias.
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