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  • Title: Identification of a somatostatin-14-generating propeptide converting enzyme as a member of the kex2/furin/PC family.
    Author: Mackin RB, Noe BD, Spiess J.
    Journal: Endocrinology; 1991 Oct; 129(4):2263-5. PubMed ID: 1680673.
    Abstract:
    A propeptide converting enzyme capable of producing somatostatin-14 has been identified and partially characterized from anglerfish pancreatic islets. Results from N-terminal protein sequence analysis indicate that this enzyme is a member of the kex2/furin/PC family. This observation provides strong corroborative evidence that the kex2/furin/PC protease family is involved in propeptide conversion. Comparison of the obtained protein sequence with the cDNA sequence of mammalian PC2 also suggests that the active enzyme is derived from a precursor by cleavage at a site containing four consecutive basic amino acids.
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