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  • Title: Improving nanoprobes using surface-enhanced Raman scattering from 30-nm hollow gold particles.
    Author: Schwartzberg AM, Oshiro TY, Zhang JZ, Huser T, Talley CE.
    Journal: Anal Chem; 2006 Jul 01; 78(13):4732-6. PubMed ID: 16808490.
    Abstract:
    We report the development of nanoprobes that exploit the surface-enhanced Raman scattering (SERS) from nonaggregated, hollow, gold nanospheres (HGNSs). The homogeneity of the HGNSs leads to a nearly 10-fold improvement in signal consistency over standard silver SERS substrates, which translates into a significant increase in sensitivity and dynamic range for the model application of pH sensing. Moreover, the small size (30-nm diameter) of these SERS-active nanoparticles represents a major step in advancing sensing technology based on SERS, making this technology more amenable to intracellular sensing.
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