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  • Title: Topographic patterns of small subcortical infarcts associated with MCA stenosis: a diffusion-weighted MRI study.
    Author: Wang X, Lam WW, Fan YH, Graham CA, Rainer TH, Wong KS.
    Journal: J Neuroimaging; 2006 Jul; 16(3):266-71. PubMed ID: 16808829.
    Abstract:
    BACKGROUND AND PURPOSE: Small subcortical infarcts (SSI, maximum lesion diameter < or =2.0 cm) are usually considered as infarcts caused by small vessel disease. However, SSI can also be associated with large artery occlusive disease such as middle cerebral artery (MCA) stenosis. We performed a prospective study to investigate the relationship between MCA stenosis and SSI distribution and further to investigate the mechanism of SSI caused by MCA stenosis. METHODS: Magnetic resonance angiography (MRA) and diffusion-weighed MRI (DWI) of consecutive acute ischemic stroke patients with recent SSI were studied. The distribution of acute infarcts on DWI was categorized as cortical infarct (CI), border zone infarct (BI), or perforating artery infarct (PAI). RESULTS: Totally, 93 cases were recruited, among which 12 had single SSI with MCA stenosis (group 1) and 26 patients had multiple SSI with MCA stenosis (group 2), while 55 patients without MCA stenosis had single SSI (group 3). For patients with single SSI and MCA stenosis, 6 had BI and 6 had PAI; for patients with multiple SSI and MCA stenosis, 25 had BI, 4 had PAI and 9 had CI (compared with group 1: P= .001); for patients with single SSI but without MCA stenosis, 20 had BI and 35 had PAI (compared with group 1: P= .58). CONCLUSION: Multiple acute infarcts along the border zone are the commonest pattern in small infarcts with MCA stenosis, especially among those with multiple acute infarcts. Our data suggest that hemodynamic compromise and artery-to-artery embolism may be both important factors for infarcts in patients with MCA stenosis.
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