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  • Title: Successful pregnancy after D-penicillamine therapy in a patient with Wilson's disease.
    Author: Soong YK, Huang HY, Huang CC, Chu NS.
    Journal: J Formos Med Assoc; 1991 Jul; 90(7):693-6. PubMed ID: 1681022.
    Abstract:
    Infertility and amenorrhea are reported in most cases of Wilson's disease. In this report, we describe a case of Wilson's disease with pancytopenia and liver cirrhosis for over 4 years, without any specific treatment. After 2 years of D-penicillamine therapy, the patient became pregnant and delivered a liver mature female baby with a body weight of 2,800 g. Both before the pregnancy and after delivery, brainstem auditory evoked potential studies showed similar bilaterally abnormal prolongation in the III-V and I-V intervals. In visual evoked potentials, the P 100 latency was delayed bilaterally. Although serial evoked potential studies failed to show any improvement, a successful pregnancy was proven to be possible in a patient with Wilson's disease who had received regular D-penicillamine treatment.
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