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  • Title: Should phosphodiesterase 5 selective inhibitors be used for uterine relaxation?
    Author: Méhats C, Schmitz T, Breuiller-Fouché M, Leroy MJ, Cabrol D.
    Journal: Am J Obstet Gynecol; 2006 Jul; 195(1):184-5. PubMed ID: 16813753.
    Abstract:
    Sildenafil citrate is a phosphodiesterase 5-selective inhibitor used successfully in treating erectile dysfunction. High doses of sildenafil can inhibit myometrial contractions. However, no study has demonstrated a role for phosphodiesterase 5 in myometrial contractility. No clinical trial using sildenafil to promote uterine relaxation should be initiated based on the currently available data.
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