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  • Title: A combination solution for routine pupillary dilation.
    Author: Krumholz DM, Portello JK, Rosenfield M, Rosenbaum JD.
    Journal: Optometry; 2006 Jul; 77(7):350-3. PubMed ID: 16814239.
    Abstract:
    BACKGROUND: This study investigated the ability of a combination drop containing reduced concentrations of tropicamide and phenylephrine to produce pupillary dilation adequate for routine fundoscopy. METHODS: One eye of each subject (N = 28; age range, 21 to 40 years; median, 23 years) was dilated with 1 drop of a solution containing 0.5% tropicamide and 2.5% phenylephrine (0.5T/2.5P). The other eye was dilated with 1 drop of either of 2 mixtures: 0.5% tropicamide and 1.25% phenylephrine (0.5T/1.25P, N = 15; median age, 23 years), or 0.25% tropicamide and 1.25% phenylephrine (0.25T/1.25P, N = 13; median age, 23 years). A topical anesthetic was administered before instilling the mydriatic agents. Pupil diameter was measured from a flash photograph taken every 15 minutes for 3 hours. There was no significant difference in pupil diameter between eyes dilated with the 0.5T/1.25P test solution and the 0.5T/2.5P control solution for the first 75 minutes after instillation (P = 0.41). All pupils reached their maximum diameter 60 minutes after drop instillation; where no significant difference was observed between the 3 mydriatic solutions (P = 0.81). All pupils were at least 7 mm in diameter 30 minutes after drop instillation, and this size was maintained for at least another 75 minutes for all solutions. CONCLUSIONS: Combination preparations of reduced concentrations of tropicamide and phenylephrine can produce clinically adequate mydriasis.
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