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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: Motor cortex reorganisation in Parkinson's disease.
    Author: Thickbroom GW, Byrnes ML, Walters S, Stell R, Mastaglia FL.
    Journal: J Clin Neurosci; 2006 Jul; 13(6):639-42. PubMed ID: 16814549.
    Abstract:
    Transcranial magnetic stimulation mapping of the motor cortical projection to the hand was performed in a group of patients with Parkinson's disease (PD) of variable duration to determine whether there is evidence of cortical reorganisation. Map shifts were found in the majority of PD cases (12/15), in untreated early cases as well as treated cases of longer duration, and there was a correlation between inter-side difference in the severity of PD symptoms (Unified Parkinson's Disease Rating Scale) and interhemispheric map displacement (r=0.60; P=0.018). These findings indicate that there is reorganisation of the corticomotor representation of the hand in PD, even at a relatively early stage of the disease, and suggest a dynamic process of reorganisation in the motor cortex due to an increase in the pallidal inhibitory inputs to the thalamo-cortical projections.
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