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  • Title: A comparative clinical study for the evaluation of antianxiety agents, (lorazepam, diazepam and placebo), in neurosis.
    Author: Itoh H, Ohtsuka N, Kamishima K, Kaizawa S, Miura S.
    Journal: Folia Psychiatr Neurol Jpn; 1977; 31(1):25-35. PubMed ID: 16815.
    Abstract:
    To evaluate the clinical effects of lorazepam on neurosis, a double-blind controlled trial by group comparison procedure was carried out using diazepam and placebo as control drugs. The clinical improvement and aggravation rates by means of a variety of assessment of change were compared between each of the two active drugs and placebo. The superiority, characteristics of therapeutic effects and minor side effects of lorazepam which is similar to those of diazepam, a standard benzodiazepine anxiolytic for the treatment of neurosis, were demonstrated. From this study, many important problems which might be influenced upon the outcome of the pharmacotherapy on neurotics, such as positive and negative placebo effects, aggravation and drop-out during the trial, were also evaluated.
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