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  • Title: [The modulatory action of superlow doses of mediators on the functional activity of the neuronal membrane].
    Author: Aĭrapetian SN, Carpenter DO.
    Journal: Zh Evol Biokhim Fiziol; 1991; 27(2):146-51. PubMed ID: 1681636.
    Abstract:
    It was shown that acetylcholine and gamma-aminobutyric acid at extremely low concentrations, which do not activate receptor-binding ionic channels, modulate the activity of NA-K-pump and Na:Ca exchange, the intracellular level of cAMP and chemosensitivity of the neuronal membrane. These data provide a new evidence in support for Koshtoiants's enzymochemical hypothesis in which synaptic transmitters are considered to be metabolic modulators for postsynaptic neurones.
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