These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Ultrastructural changes of the skin induced by human leukocyte elastase and cathepsin G.
    Author: Glinski W, Kuligowski M, Pierozynska-Dubowska M, Glinska-Ferenz M, Jablonska S.
    Journal: Acta Derm Venereol; 1991; 71(4):277-82. PubMed ID: 1681641.
    Abstract:
    Human neutrophil elastase and cathepsin G at a concentration of 10(-6) M were found to attack various substrates when normal skin biopsy specimens were incubated at 37 degrees C for 1 h with either of these enzymes. Elastase damaged primarily hemidesmosomes, leading to the epidermal cleavage from the dermis, whereas cathepsin G damaged the membrane structures. Both these neutral proteinases were highly specific to basal lamina of blood vessels. This indicates that neutrophil elastase and neutrophil cathepsin G may play different roles in various skin diseases related to enhanced activity and infiltration of neutrophils.
    [Abstract] [Full Text] [Related] [New Search]