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  • Title: Thermal inactivation of different measles virus strains.
    Author: Klamm H, Pollex G, Henning U.
    Journal: Acta Virol; 1991 Apr; 35(2):200-2. PubMed ID: 1681719.
    Abstract:
    The kinetics of thermal inactivation at 45 degrees C was investigated with different measles virus strains. The decrease of virus infectivity was determined by plaque counting test. The inactivation velocity of strains Schwarz, Moraten, Woodfalk, L16/SSW, L16/Moscow, and L16/S3 based on regression curve analysis (virus titres by time) allowed to divide them into 3 categories according to temperature sensitivity. Our results showed that development of a thermostable measles vaccine does not require selection of a thermoresistant virus variant if certain conditions for virus harvest are fulfilled.
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