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  • Title: Lipid oxidation may reduce the quality of a fresh-frozen bone allograft. Is the approved storage temperature too high?
    Author: Laitinen M, Kivikari R, Hirn M.
    Journal: Acta Orthop; 2006 Jun; 77(3):418-21. PubMed ID: 16819680.
    Abstract:
    BACKGROUND: International standards indicate that bone allografts for human use should be stored in a -40 degrees C or colder environment and the storage time should be up to 5 years. Bone allografts contain lipids which oxidate and become toxic with time. MATERIAL AND METHODS: We determined lipid oxidation in femoral head bone allografts by headspace gas chromatography at different storage temperatures and storage times. RESULTS: We found that lipid oxidation in fresh-frozen bone allograft was influenced by storage temperature and storage time. Lipid oxidation was significantly more rapid at -30 degrees C than at -70 degrees C. Even at -70 degrees C, however, some oxidation occurred but it was quite minimal after 3 years. INTERPRETATION: Because of the negative effects of lipid oxidation, we recommend a storage temperature of -70 degrees C or lower for bone allografts.
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