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  • Title: Clinical effectiveness of tumor markers in squamous cell carcinoma of the larynx.
    Author: Eleftheriadou A, Chalastras T, Ferekidou E, Kyriou L, Yiotakis I, Pappas Z, Ferekidis E, Kandiloros D.
    Journal: Anticancer Res; 2006; 26(3B):2493-7. PubMed ID: 16821638.
    Abstract:
    BACKGROUND: The aim of this study was to examine and compare the value of the serum tumor markers CYFRA 21-1, TPA-M, SCCA and CEA in squamous cell carcinoma (SCC) of the larynx. Moreover, their possible clinical applications were studied. MATERIALS AND METHODS: The serum levels of CYFRA 21-1, TPA-M, SCCA and CEA were measured in 79 patients with histologically-proven squamous cell carcinoma (SCC) of the larynx before and after treatment and in 77 healthy volunteers. The association of the results with the clinicopathological characteristics was investigated. RESULTS: The study showed that none of the markers revealed a significant sensitivity; TPA-M indicated a positive correlation with the grade of differentiation. CEA indicated a positive correlation only with distant metastasis. CONCLUSION: Among the four markers, only TPA-M may play a role in monitoring the success of therapy and follow-up in patients with SCC of the larynx.
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