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  • Title: Bioactive glass S53P4 in frontal sinus obliteration: a long-term clinical experience.
    Author: Peltola M, Aitasalo K, Suonpää J, Varpula M, Yli-Urpo A.
    Journal: Head Neck; 2006 Sep; 28(9):834-41. PubMed ID: 16823870.
    Abstract:
    BACKGROUND: Synthetic, osteoconductive, and antimicrobial bioactive glass (BAG) has been used in many surgical applications. METHODS: BAG was used as obliteration material in a series of osteoplastic frontal sinus operations on 42 patients suffering from chronic frontal sinusitis, which could not be cured with other means of treatment. RESULTS: Accurate obliteration of sinuses was achieved in 39 patients. Uneventful recovery and clinical outcome were seen in 92% of the patients. Histopathologic samples harvested at 1, 5, and 10 years after obliteration revealed a healing process progressing from the fibrous tissue phase to bone formation with scattered fibrous tissue and bony obliteration maintaining BAG granule remnants. Fourier-transform infrared (FTIR) studies showed bone produced by BAG to be similar to natural frontal bone. Micorobiologic cultures obtained with histologic samples revealed no growth of bacteria. CONCLUSIONS: BAG appears to be a reliable frontal sinus obliteration material, providing favorable conditions for total bony sinus obliteration.
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