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  • Title: Mucosal immune responses to meningococcal C polysaccharide-protein conjugate in mice.
    Author: Cuello M, Cabrera O, del Campo JM, Parajón E, Sotolongo F, Camaraza MA, Arnet A, Suárez M, Pérez O.
    Journal: Vaccine; 2006 Apr 12; 24 Suppl 2():S2-72-3. PubMed ID: 16823934.
    Abstract:
    Mucosal delivery of vaccines represents an attractive approach because this is a region of first contact point for inhaled antigens. We have obtained a meningococcal group C polysaccharide-tetanus toxoid conjugate (MGCP-TT) and evaluated it for intranasal route in mice. The conjugate was obtained by a developed method in our laboratory. The specific IgA in saliva and specific IgA and IgG in serum were measured by ELISA methods and bactericidal antibodies in sera against a meningococcal group C strain were measured. The conjugated elicited a significant increase in anti-MGCP salivary IgA and serum IgG and bactericidal antibodies concentrations, while specific serum IgA was not observed. These results indicated that after conjugation, there was a change in the responses for MGCP from thymus-independent to thymus-dependent and that it was effective by intranasal route.
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