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  • Title: [Acute exacerbation of chronic obstructive pulmonary disease and antibiotics: analysis of comparative trials].
    Author: Garré M, Garo B, Ansart S, Le Berre R.
    Journal: Med Mal Infect; 2006; 36(11-12):690-6. PubMed ID: 16824719.
    Abstract:
    OBJECTIVE: The authors had for aim to assess the role of antibiotics in acute exacerbations of chronic obstructive pulmonary disease (COPD). METHODS: Comparative antibiotic trials were collected through systematic search on Medline data base--well-designed studies were selected. RESULTS: Eight equivalence studies were selected. No clear difference between antibiotics was demonstrated. The shortest treatment was as effective as the longest. CONCLUSION: No antibiotic has demonstrated its superiority. A new generation of antibiotic comparative trials for exacerbation of COPD is clearly needed.
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