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  • Title: Clinico-histopathological characteristics of clopidogrel-induced hepatic injury: case report and review of literature.
    Author: Höllmüller I, Stadlmann S, Graziadei I, Vogel W.
    Journal: Eur J Gastroenterol Hepatol; 2006 Aug; 18(8):931-4. PubMed ID: 16825915.
    Abstract:
    Clopidogrel is a thienopyridine derivative with a relatively low occurrence of adverse side effects. Increasing evidence, however, suggests that clopidogrel may cause severe liver injury. Until now, five cases of clopidogrel-induced acute hepatitis have been reported. We describe the case of an 80-year-old man who developed symptomatic liver disease 6 weeks after 1x75 mg/day clopidogrel intake as adjunctive antiplatelet therapy for a renal artery stent implantation. Histological examination revealed severe acute hepatitis with extensive hepatocanalicular cholestasis and focal cell necrosis with a preferential zone-3 distribution of hepatic damage. In the present paper, we describe the clinico-histopathological characteristics of a case of clopidogrel-induced acute hepatitis and discuss the current literature.
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