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  • Title: [Effect of platelet derived growth factor BB on healing of medial collateral ligament in rats].
    Author: Ren Y, Li W, Liu X.
    Journal: Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi; 2006 Jun; 20(6):616-9. PubMed ID: 16827384.
    Abstract:
    OBJECTIVE: To examine an effect of the locally-used platelet derived growth factor-BB (PDGF-BB) on the healing of the medial collateral ligament (MCL) in the knee joints of rats. METHODS: Forty-eight rats were equally randomly divided into 2 groups: the experimental group (group A) and the control group (group B). MCL of all the rats were ruptured to establish the wound models. In group A, 5 microg of PDGF-BB was locally injected in the wound of each rat and then the wound was sutured; but in group B, the wound was only sutured. After 2 weeks, histological evaluations were performed to determine whether PDGF-BB could promote the healing of MCL. RESULTS: There were significantly more fibroblasts formed during the ligament healing process in group A than in group B (213.44 +/- 15.32 vs. 180.42 +/- 12.78, P < 0.01). The fibroblasts were more mature and more regularly-arranged in group A than in group B. The type, content, and crosslink of the collagen were improved to a greater extent in group A than in group B (P < 0.01). CONCLUSION: PDGF can promote the healing of the injured ligament.
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