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  • Title: Random albumin/creatinine ratio for quantification of proteinuria in manifest pre-eclampsia.
    Author: Wikström AK, Wikström J, Larsson A, Olovsson M.
    Journal: BJOG; 2006 Aug; 113(8):930-4. PubMed ID: 16827832.
    Abstract:
    OBJECTIVE: 1) To assess the correlation between urine albumin/creatinine ratio (ACR) and 24-hour urine albumin excretion in women with pre-eclampsia, 2) to study the influence of potential confounders on this correlation and 3) to assess the variability of ACR between voids during a 24-hour period. DESIGN: Prospective study. SETTING: Fetal maternity ward, university hospital. POPULATION: Women with pre-eclampsia scheduled for quantitative albumin measurement with a 24-hour urine collection. METHODS: Random urine samples were obtained for analysis of ACRs during the time of 24-hour urine collections in 31 women. ACRs were also measured from the complete 24-hour collections. In five additional women, serial urine samples were obtained during the 24-hour collection. MAIN OUTCOME MEASURES: Correlation between ACRs and albumin amount in 24-hour urine samples. Variability of the ACRs during a 24-hour collection. RESULTS: The random ACR was poorly correlated to 24-hour excretion of urine albumin (R(2)= 0.42). Adjustment for maternal age and nifedipine medication significantly (P= 0.044 and P= 0.023, respectively) improved the correlation (R(2)= 0.60). The mean variability (highest/lowest) of ACR during a 24-hour period was 222%. The ACR from the 24-hour collection had an excellent correlation to 24-hour excretion of urine albumin (R(2)= 0.96). CONCLUSIONS: In women with pre-eclampsia, random ACR is not stable during the day and cannot predict 24-hour urine protein excretion accurately. ACR from the 24-hour collection is an accurate predictor of total albumin amount and can be used to minimise errors from incomplete collections.
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