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  • Title: A duplicated nitrotienyl derivative with antimycobacterial activity: synthesis, X-ray crystallography, biological and mutagenic activity tests.
    Author: Rando DG, Doriguetto AC, Tomich de Paula da Silva CH, Ellena J, Sato DN, Leite CQ, Varanda EA, Ferreira EI.
    Journal: Eur J Med Chem; 2006 Oct; 41(10):1196-200. PubMed ID: 16828526.
    Abstract:
    A duplicated nitrotienyl derivative was obtained as a by-product from the synthesis of a proposed molecular hybrid of a nitrotienyl derivative and isoniazid with an expected dual antimycobacteria mechanism. The structure was shown to be the 5,5'-dinitro-2-(2,3-diaza-4-(2'-tienyl)buta-1,3-dienyl)tiophene by X-ray crystallography. The minimal inhibitory concentration (MIC) determination of this compound proved to be promising against Mycobacterium pathogenic strains such as M. avium and M. kansasii, although it had a high level of mutagenicity, as observed in mutagenic activity tests.
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