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  • Title: v-erbA oncogene abrogates growth inhibition of chicken embryo fibroblasts induced by retinoic acid.
    Author: Desbois C, Pain B, Guilhot C, Benchaibi M, Ffrench M, Ghysdael J, Madjar JJ, Samarut J.
    Journal: Oncogene; 1991 Nov; 6(11):2129-35. PubMed ID: 1682867.
    Abstract:
    Retinoic acid inhibits chicken embryo fibroblast (CEF) proliferation by altering the G1 phase of the cell cycle with induction of a strong increase in the generation time. This growth-inhibitory response to retinoic acid is abrogated by expression of the v-erbA oncogene, suggesting an interference between retinoic acid receptors and the v-ErbA oncoprotein. Moreover, CEF expressing either the v-src, v-jun or v-fos oncogenes are also insensitive to retinoic acid treatment. In contrast, CEF expressing either the v-myc, v-myb-ets, v-mil, v-sea or v-erbB oncogenes are still sensitive to retinoic acid. These data strongly suggest functional interferences between the retinoic acid receptors and the AP-1 transcription factor complex in the control of expression of genes involved in CEF proliferation.
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