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  • Title: Selection of the cutaneous intraepithelial gammadelta+ T cell repertoire by a thymic stromal determinant.
    Author: Lewis JM, Girardi M, Roberts SJ, Barbee SD, Hayday AC, Tigelaar RE.
    Journal: Nat Immunol; 2006 Aug; 7(8):843-50. PubMed ID: 16829962.
    Abstract:
    Intraepithelial lymphocytes constitute a group of T cells that express mainly monospecific or oligoclonal T cell receptors (TCRs). Like adaptive TCR alphabeta+ T cells, intraepithelial lymphocytes, a subset enriched in TCR gammadelta+ T cells, are proposed to be positively selected by thymically expressed self agonists, yet no direct evidence for this exists at present. Mouse dendritic epidermal T cells are prototypic intraepithelial lymphocytes, displaying an almost monoclonal TCR gammadelta+ repertoire. Here we describe an FVB substrain of mice in which this repertoire was uniquely depleted, resulting in cutaneous pathology. This phenotype was due to failure of dendritic epidermal T cell progenitors to mature because of a heritable defect in a dominant gene used by the thymic stroma to 'educate' the natural, skin-associated intraepithelial lymphocyte repertoire to be of physiological use.
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