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  • Title: Importance of interphase nucleolar organizer regions in tumor pathology.
    Author: Derenzini M, Trerè D.
    Journal: Virchows Arch B Cell Pathol Incl Mol Pathol; 1991; 61(1):1-8. PubMed ID: 1683059.
    Abstract:
    The importance of the distribution of silver-stained nucleolar organizer regions (Ag-NORs) in interphase nuclei for diagnostic and prognostic purposes in tumor pathology has been reviewed. The available data demonstrated that interphase Ag-NOR evaluation may be of help in distinguishing malignant from hyperplastic or normal cells. On the other hand, there is increasing evidence that a relationship exists between the quantity of interphase Ag-NORs and the prognosis of malignant tumors: the greater the number of interphase Ag-NORs, the worse is the prognosis. This can be explained by the observation that the interphase Ag-NOR quantity is strictly related to the cell proliferation rate. The procedures used for the measurement of the interphase Ag-NOR quantity are also critically discussed.
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