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  • Title: [Bone tissue in osteogenesis imperfecta: light and electron microscopic studies].
    Author: Osipenkova-Vichtomova TK.
    Journal: Arkh Patol; 2006; 68(3):20-5. PubMed ID: 16830619.
    Abstract:
    Osteogenesis imperfecta was studied by light and electron microscopic techniques in 36 cases, of them there were 10 postmortem and 26 bone biopsies. The persons' age was from 0 to 38 years. There were 25 males and 11 females. The microscopic studies indicated a decrease in the basic substance and an increase in the number of osteocytes. The electron microscopic studies revealed a reduction in the granular endoplasmic reticulum, as well as matrix swelling in the mitochondria, their crista degeneration, and the presence of mitochondrial hydroxyappatite; non-uniform mineralization of collagenous structures, their disintegration, a change in the diameter of collagenous fibril, and a decrease in their transversal lines.
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