These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [The expression of galectin-3 in nodular thyroid goitre].
    Author: Chen WJ, Yu MH, Xu Y, Shen J.
    Journal: Zhonghua Nei Ke Za Zhi; 2006 Jun; 45(6):452-5. PubMed ID: 16831319.
    Abstract:
    OBJECTIVE: To investigate the expression of galectin-3 in benign and malignant thyroid nodules. METHODS: Galectin-3 expression was assayed with immunohistochemical and RT-PCR methods in thyroid specimens. RESULTS: The majority of the specimens of thyroid carcinomas expressed galectin-3 with immunohistochemical and RT-PCR methods (89.7% and 91.7%) and the expression was significantly in different histological types. Papillary and follicular thyroid malignancies showed high expression of galectin-3 (100% positive). Comparing the specimens of thyroid carcinomas with metastases and those without metastases, the expression of galectin-3 was significantly higher in the former than in the latter. Among 25 specimens of benign adenomas and 13 specimens of nodular hyperplasia, only 3 were weakly positive and other were negative. Neither 10 specimens of normal thyroid tissue nor 25 specimens of paracarcinomatous thyroid tissue expressed galectin-3. CONCLUSION: Galectin-3 may be used as a marker for differentiating benign and malignant thyroid nodules.
    [Abstract] [Full Text] [Related] [New Search]