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  • Title: Diffuse cerebral vasoconstriction (Call-Fleming syndrome) and stroke associated with antidepressants.
    Author: Noskin O, Jafarimojarrad E, Libman RB, Nelson JL.
    Journal: Neurology; 2006 Jul 11; 67(1):159-60. PubMed ID: 16832100.
    Abstract:
    Call-Fleming syndrome is a reversible segmental vasoconstriction of cerebral arteries manifested by a "thunderclap" headache and focal neurologic symptoms. Although of unknown etiology, it has been reported in association with vasoactive sympathomimetic drugs. The authors report Call-Fleming syndrome in two patients with history of antidepressant use. Although the association is hypothetical, the authors suggest consideration of Call-Fleming syndrome in patients presenting with headache, focal deficits, and evidence of cerebral ischemia during antidepressant use.
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