These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Effect of activated charcoal on the absorption of amiodarone.
    Author: Kivistö KT, Neuvonen PJ.
    Journal: Hum Exp Toxicol; 1991 Sep; 10(5):327-9. PubMed ID: 1683545.
    Abstract:
    1 The ability of activated charcoal to prevent the absorption of amiodarone was studied in 18 healthy volunteers, divided into three groups of six subjects. 2 All subjects were administered a single dose of 400 mg amiodarone; one group ingested the drug with water only (control) and the second with 25 g of activated charcoal as a water suspension. The subjects in the third group were given 25 g of charcoal immediately after the 1.5 h blood sample. 3 The extent of amiodarone absorption was reduced by about 98% by simultaneously administered charcoal (P less than 0.001); taking charcoal 1.5 h after amiodarone still resulted in a 50% reduction in amiodarone bioavailability (P less than 0.05). 4 These results indicate that activated charcoal should be effective in preventing amiodarone absorption in acute poisoning.
    [Abstract] [Full Text] [Related] [New Search]