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  • Title: [A gastric stromal tumor (GIST) with a prolonged partial response to a reduced dose of imatinib mesilate].
    Author: Nakatani K, Tanabe S, Nishimura K, Shimoda T, Azuma M, Katada C, Sasaki T, Higuchi K, Koizumi W, Saigenji K.
    Journal: Gan To Kagaku Ryoho; 2006 Jul; 33(7):997-1000. PubMed ID: 16835496.
    Abstract:
    A 78-year-old woman was admitted to our hospital because of tarry stools. A gastric stromal tumor with liver metastasis was diagnosed. Treatment with imatinib mesilate was begun in a dose of 400 mg daily. After 1 month, the primary tumor showed a partial response; the response of the liver metastasis was stable disease. However, grade 2 edema, leukocytopenia, and anemia developed, and the dose of imatinib mesilate was reduced to 200 mg daily. The adverse reactions resolved promptly, and a partial response of both the primary tumor and liver metastasis to imatinib mesilate has been maintained for 28 months. Strategies for lowering the dose of imatinib mesilate are reviewed.
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