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  • Title: Photobiological information obtained from XPA gene-deficient mice.
    Author: Horio T, Miyauchi-Hashimoto H, Kuwamoto K, Yamazaki F, Okamoto H.
    Journal: Photochem Photobiol; 2007; 83(1):218-24. PubMed ID: 16836470.
    Abstract:
    The XPA gene-deficient mouse, an animal model of xeroderma pigmentosum (XP), develops enhanced photobiologic reactions including acute inflammation, immunosuppression and skin carcinogenesis, because of the defect in the excision repair of ultraviolet-induced DNA lesions. The results strongly suggest that nuclear DNA is an important chromophore to initiate acute and chronic skin damages. The model mouse is a useful experimental animal not only to investigate the mechanisms of photosensitivity in XP, but also to study physiological photobiology in humans, because photobiologic reactions are greatly intensified in this mouse.
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