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  • Title: Structure-activity relationships for the linker in a series of pyridinyl-alkynes that are antagonists of the metabotropic glutamate receptor 5 (mGluR5).
    Author: Bach P, Nilsson K, Svensson T, Bauer U, Hammerland LG, Peterson A, Wållberg A, Osterlund K, Karis D, Boije M, Wensbo D.
    Journal: Bioorg Med Chem Lett; 2006 Sep 15; 16(18):4788-91. PubMed ID: 16837196.
    Abstract:
    Studies of structure-activity relationships for the linker in a new series of metabotropic glutamate receptor 5 antagonists are presented together with in vitro and in vivo pharmacokinetic data.
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