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  • Title: Chromosomal localization of the human gene for annexin V (placental anticoagulant protein I) to 4q26----q28.
    Author: Tait JF, Frankenberry DA, Shiang R, Murray JC, Adler DA, Disteche CM.
    Journal: Cytogenet Cell Genet; 1991; 57(4):187-92. PubMed ID: 1683830.
    Abstract:
    Annexin V is a member of a new family of calcium-dependent phospholipid-binding proteins. It has been previously isolated as placental anticoagulant protein I, inhibitor of blood coagulation, vascular anticoagulant-alpha, endonexin II, lipocortin V, placental protein 4, and anchorin CII. The human gene encoding annexin V (ANX5) was localized to 4q26----q28 by in situ hybridization with a cDNA probe and polymerase chain-reaction (PCR) analysis of a human x hamster hybrid cell panel. The regional localization to 4q26----q28 was supported by Southern-blot analysis of a human cell line with a deletion in 4q23----q27. This localization overlaps but differs slightly from the previous assignment of ANX5 to 4q28----q32. Digestion with PvuII and TaqI identified polymorphisms at the ANX5 locus; the PvuII polymorphism could also be detected by PCR analysis.
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