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  • Title: Immunophenotyping of skin cells during healing of suction blister injury.
    Author: Reusch MK, Mansbridge JN, Nickoloff BJ, Morhenn VB.
    Journal: Dermatologica; 1991; 183(3):179-83. PubMed ID: 1683839.
    Abstract:
    The time course of appearance and the dynamic changes of immunocompetent cells were assessed in human skin following sterile suction blister would healing. During epidermal regeneration, a local increase in Langerhans cells (LC) and the appearance of a mononuclear cell infiltrate were observed. Initially, T cells were exclusively of the T helper/inducer subtype, whereas during the later stages of the healing process an increasing number of cytotoxic/suppressor T cells (up to 30%) was observed. Keratinocytes of neither the adjacent nor the newly formed epidermis expressed HLA-DR over the course of the wound-healing process. Our results suggest that immune-competent cells such as T cells and LC may play an important role in the regulation of the wound-healing process.
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